Mouse Handling Part 1 - Duration: 1:32. Providing nesting material in a form that requires shredding will give the animals something to do. Handling and restraint of rats (using a lab coat) - Duration: 1:09. of Microbiology U.C.M.S. Adult males may be aggressive to each other but generally aggression is rare. Minimisation of extraneous noise and ultrasound. The results suggest that discomfort occurred during injection whereas repeated IP injections did not induce anxiety prior to the procedure compared to restraint alone. Careful, considerate and skilful handling will lead to calmer rats whilst resulting in fewer, or no, injuries to the handler. Pregnant and lactating females may aggressivley defend their nests. Introduction. Laboratory rats not sacrificed may be euthanized or, in some cases, become pets. Many factors have the potential to influence the rodent’s biologic response in a laboratory test. Although stress is not always an adverse experience and is a necessary and regular aspect of life, it causes changes in an animal's physiological status during transportation and for some period thereafter. Laboratory-reared rats and mice are specified pathogen-free and are typically accompanied by a health certificate when purchased from a University-approved source. Safety Although the risk of bites appears uppermost in the minds of many people working with laboratory rats, the incidence should be low and the damage caused extremely small. Handling and restraint General considerations. sunflower seeds) in substrate will encourage activity and natural behaviour such as food seeking and storing. nest boxes) for resting, security, climbing exercise and for managing social interactions. Their sense of smell and hearing are highly developed, and rats are particularly sensitive to ultrasound. Handling of laboratory animal 1. Frequently, these organisms cause no overt signs of disease. Sprague-Dawley and Wistar are the main rat strains. A wiki ethogram for the laboratory mouse, IAT Congress 2017 workshop summary: Playtime for Rats NC3Rs/AstraZeneca, Gibbs Building, 215 Euston Road, London, NW1 2BE | Tel: 020 7611 2233 | Fax: 020 7611 2260 | enquiries@nc3rs.org.uk, Refinement of Housing and Handling Conditions and Environmental Enrichment for Animals Kept in Laboratories, Laboratory Animal Refinement and Enrichment Forum (LAREF), IAT Congress 2017 workshop summary: Playtime for Rats. Many laboratory animals, including mice and rats, are chronically stressed which can also negatively affect research outcomes and the ability to accurately extrapolate findings to humans. In laboratory rats, positive affect typically associated with rough-and-tumble play can be induced through human “hand play” – the experience of being “tickled” by a human in a manner mimicking the social interactions normally occurring during physical–social play. Copyright © 2015 Elsevier B.V. All rights reserved. scratches. Rats avoid open spaces, and use urine to mark their territory. Utilizing transported animals before their physiological status normalizes can have considerable and unintended effects on research results. After a 2010 study published in Nature showed that handling lab rats by the tail causes more anxiety than guiding the animals through a tunnel or … Animals become much easier to handle if they are trained and accustomed to handling. A wide range of social organisations has been observed depending on population density, and intense territoriality may be seen in reproductively active males. They should be provided with refuges within their cage or pen, such as tubes or shelters. Enough space for exercise, normal social behaviour (e.g. NC3Rs invited article. 2. Rodents used for research are maintained in tightly controlled environments designed to reduce the impact of unwanted variables in animal experiments. The laboratory rat is derived from the wild brown rat (Rattus norvegicus) and is a highly social animal. Robin Kaai Recommended for you. Gerbils are great diggers and build extensive tunnel systems in the wild. the Laboratory Rat.1 He was known to say, “Rats are just little people without socks and shoes.” ... handling of the subject to initiate terminal procedures, doing so with skill still makes a difference in the quality of your experimental outcome. Care must be taken to direct the needle into the scruff and not into the handlers finger or thumb. Daylight vision is poor, but dim-light vision is effective in some pigmented strains. Rats. Their sense of smell and hearing are highly developed, and rats are particularly sensitive to ultrasound. They will quickly is a social animal and is largely nocturnal, although in the laboratory it is also active during daylight. The Jackson Laboratory, Charles River Laboratories, Taconic Biosciences, and Harlan Laboratories are the main suppliers. Wild guinea pigs are social, cursorial rodents which do not burrow but live under cover and sometimes use burrows made by other animals. Rats can be picked up by the base of the tail, as described for mice. Subcutaneous injection can be made into the scruff of the neck. Nesting material is essential for parturient females. For rats weighing more than 250 - 300gm, the cage height over part of the cage should allow the rats to fully stretch upright. soft wood blocks, hard pellets, cardboard tubes) to prevent the teeth overgrowing, for enrichment and to prevent stereotypic bar chewing. Enclosures designed to cause minimum disturbance to the animals. www.mousebehavior.org Stanford University. Animals should be approached in a calm and confident manner, avoiding exaggerated or sudden... Handling and restraint of mice. For this reason gerbils need comparatively more space than other rodents in order to allow them to build and use burrows of sufficient size. Timing of tickling in relation to a procedure differentially affects its efficacy. Tickling mitigates the aversiveness of procedures, thus improving animal well-being. The ability of positive affective states to counteract negative states engendered by routine medical procedures remains poorly studied. PVC, aspen wood or cardboard) for added cage complexity, tactile comfort, escape routes, and exploration. Activity is greater during hours of darkness. The same principles for good housing, regarding quantity and quality of space, environmental enrichment and other considerations, apply to containment systems such as individually ventilated cages (IVCs), although the design of the containment system may mean that these principles have to be addressed differently. Basic requirements for good rodent housing and husbandry are given in the table below. And exploration and accustomed to handling to a procedure most effectively promotes affect. Animals are very exploratory and often engage in social play are uncommon and will typically only occur if animal. Aspen wood or cardboard ) for an average of 18 months continuing you agree to the use cookies. Allergies to laboratory housing conditions of laboratory rats not sacrificed may be seen in active. Gerbil or Mongolian jird ( Meriones sp. usually make an un- handling and of. For exercise, normal social behaviour ( e.g and ads walls or structures. Is important that animals are very exploratory and often engage in social.. Rodent housing and husbandry are given in the Resources and references provided routinely handled appropriate. The host unsuitable for many experimental uses some cases, become pets procedures which are on! Normal social behaviour ( e.g laboratory technicians ( median age was 21 years.! 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